Instituto Henriqueta Teixeira

Instituto Henriqueta Teixeira

Artigo

27.03.10

Acupuncture treatment for pain: systematic review of randomised clinical trials with acupuncture placebo acupuncture, and no acupuncture groups.

Matias Vested Madsen, physician, Peter C G°tzsche, director, Asbj°rn Hrˇbjartsson, senior researcher

ABSTRACT
Objectives To study the analgesic effect of acupuncture and placebo acupuncture and to explore whether the type of the placebo acupuncture is associated with the estimated effect of acupuncture.
Design Systematic review and meta-analysis of three armed randomised clinical trials.
Data sources Cochrane Library, Medline, Embase, Biological Abstracts, and PsycLIT.
Data extraction and analysis Standardised mean differences from each trial were used to estimate the effect of acupuncture and placebo acupuncture. The different types of placebo acupuncture were ranked from 1 to 5 according to assessment of the possibility of a physiological effect, and this ranking was meta-regressed with the effect of acupuncture.
Data synthesis Thirteen trials (3025 patients) involving a variety of pain conditions were eligible. The allocation of patients was adequately concealed in eight trials. The clinicians managing the acupuncture and placebo acupuncture treatmentswere not blinded in any of the trials.
One clearly outlying trial (70 patients) was excluded. A small difference was found between acupuncture and placebo acupuncture: standardised mean difference −0.17 (95% confidence interval −0.26 to −0.08), corresponding to 4mm (2 mm to 6 mm) on a 100 mm visual analogue scale. No statistically significant heterogeneity was present (P=0.10, I2=36%). A moderate differencewas found between placebo acupuncture and no acupuncture: standardised mean difference −0.42 (−0.60 to −0.23). However, considerable heterogeneity (P<0.001, I2=66%) was also found, as large trials reported both small and large effects of placebo. No association was detected between the type of placebo acupuncture and the effect of acupuncture (P=0.60).
Conclusions
A small analgesic effect of acupuncture was found, which seems to lack clinical relevance and cannot
be clearly distinguished from bias. Whether needling at acupuncture points, or at any site, reduces pain
independently of the psychological impact of the treatment ritual is unclear.

Baixar Arquivo Arquivo

voltar

Rua Sinval de Sá, 766
Bairro Cidade Jardim
Belo Horizonte - MG
CEP: 30.380-070
(31) 3285.1133 / henriqueta@ssrp.com.br